RELATIONSHIP OF OXALATE NEPHROPATHY AND DIGESTIVE PATHOLOGY IN CHILDREN

Authors

  • Tajieva Zebo Bakhodirovna Phd. Senior Lecturer at the Department of Pediatric Disease Propedeutics, Pediatrics and Higher Nursing. Urgen Branch of the Tashkent Medical Academy. Urgench, Uzbekistan
  • Masharipov Sanatbek Atanazarovich Head of the Department Software Engineering of Tashkent University of Information Technologies named afted Muhammad al-Khwarizmi. Urgench, Uzbekistan

Keywords:

children, metabolic (dysmetabolic) nephropathy, hyperoxaluria

Abstract

Study of the structure, combined pathology of the kidneys and the digestive system of nonmicrobial etiology are researched in this article. A survey of 120 children with oxalate nephropathy was conducted. The age of children from 3 to 14 years are examined. All children underwent general clinical studies, biochemical analysis of blood and urine, EFGDS, ultrasound of the abdominal organs and kidneys, a study of feces for dysbiosis. When oxalate nephropathy revealed a high frequency of combination of pathology of the gastrointestinal tract. The most common athologies of the digestive tract, which was detected in children with oxalate nephropathy, are: chronic gastritis (32%), biliary tract dysfunction (56%), duodenal ulcer (3%), and chronic enterocolitis (9%). Impaired bowel function, in the form of dysbiosis, was detected in 65.3% of children with oxalate nephropathy.

References

Dlin V.V., Osmanov I.M. Dysmetabolic nephropathy with oxalate-calcium crystalluria. Effective pharmacotherapy. Pediatrics. 2013. No. 42. P. 8-17. (in Russian)

de Martines, D. G. L., Gianotten, S., Wetzels, J. F. M., & van der Meijden, W. A. G. (2019).Secondary hyperoxaluria due to pancreatic insufficiency. The Netherlands journal of medicine, 77(8), 287.

Humayun Y. et al. Acute oxalate nephropathy associated with orlistat //Journal of nephropathology.– 2016. – Т. 5. – №. 2. – С. 79.

Lew S. Q., Radhakrishnan J. Chronic Kidney Disease and Gastrointestinal Disorders //Chronic Renal Disease. – Academic Press, 2020. – С. 521-539.

Ticinesi A. et al. Calcium Oxalate Nephrolithiasis and Gut Microbiota: Not just a Gut-Kidney Axis.A Nutritional Perspective //Nutrients. – 2020. – Т. 12. – №. 2. – С. 548.

Waikar S. S. et al. Association of urinary oxalate excretion with the risk of chronic kidney disease progression //JAMA internal medicine. – 2019. – Т. 179. – №. 4. – С. 542-551.

Lumlertgul N. et al. Secondary oxalate nephropathy: a systematic review //Kidney international reports. – 2018. – Т. 3. – №. 6. – С. 1363-1372.

Downloads

Published

2021-11-10

Issue

Section

Articles