GENE-GENE INTERACTION OF POLYMORPHISMS 5A/6A OF THE MMP3 GENE AND 1562 C/T OF THE MMP9 GENE IN PATIENTS WITH CEPHALGIC SYNDROME WITH AND WITHOUT CEREBRAL VASCULAR ANOMALIES
Keywords:
cephalgic syndrome, vessels, pathological tortuosity, molecular genetics.Abstract
One of the possible causes of headaches is abnormalities of cerebral vascular development. In this regard, the study of molecular-genetic manifestations of gene-gene interactions is highly relevant. Therefore, in the course of analyzing the data of molecular-genetic studies, we studied gene-gene interaction of polymorphisms 5a/6a of MMP3 gene and 1562 C/T of MMP9 gene in patients with cephalgic syndrome with and without cerebral vascular anomalies. The study of which showed certain changes characteristic for these interactions. The analysis of "gene-gene interactions" in the studied groups revealed a number of genotypic combinations. The combination of two "unfavorable genotypes" was found in 15 patients (22.7%) and 8 healthy individuals (12.3%).
References
Metalloprotinases as regulators of neoangiogenesis in malignant neoplasms./Spirina L.V., Kondakova I.V., Klishko E.V., Kakurirna G.V., Shishkin D.A.//Sib.onkol. journal.-2007-T21, No.1-C. 67-71
Biological role and regulation of matrix metalloprotinases in cancer /Davidson B., Reich R., Risberg B., Nesland L.M.//Arch.pathol.-2002-T.64, №3.-P. 47-53.
Hotko A.A. Role of matrix metalloprotinases in the development of psoriasis and associated comorbidity (review)//Saratov Scientific Medical Journal. 2003.Т.9, №3. С.582-584.
