GENE-GENE INTERACTION OF POLYMORPHISMS 5A/6A OF THE MMP3 GENE AND 1562 C/T OF THE MMP9 GENE IN PATIENTS WITH CEPHALGIC SYNDROME WITH AND WITHOUT CEREBRAL VASCULAR ANOMALIES

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Published: May 18, 2024
Keywords:
cephalgic syndrome, vessels, pathological tortuosity, molecular genetics.

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Rakhmatullayeva Gulnora
Dustmukhamedova Risolat
Tashkent Medical Academy. Department of Neurology and Medical Genetics. Tashkent, Uzbekistan

Abstract

One of the possible causes of headaches is abnormalities of cerebral vascular development. In this regard, the study of molecular-genetic manifestations of gene-gene interactions is highly relevant. Therefore, in the course of analyzing the data of molecular-genetic studies, we studied gene-gene interaction of polymorphisms 5a/6a of MMP3 gene and 1562 C/T of MMP9 gene in patients with cephalgic syndrome with and without cerebral vascular anomalies. The study of which showed certain changes characteristic for these interactions. The analysis of "gene-gene interactions" in the studied groups revealed a number of genotypic combinations. The combination of two "unfavorable genotypes" was found in 15 patients (22.7%) and 8 healthy individuals (12.3%).

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How to Cite
Rakhmatullayeva Gulnora, & Dustmukhamedova Risolat. (2024). GENE-GENE INTERACTION OF POLYMORPHISMS 5A/6A OF THE MMP3 GENE AND 1562 C/T OF THE MMP9 GENE IN PATIENTS WITH CEPHALGIC SYNDROME WITH AND WITHOUT CEREBRAL VASCULAR ANOMALIES. Galaxy International Interdisciplinary Research Journal, 12(5), 308–311. Retrieved from https://internationaljournals.co.in/index.php/giirj/article/view/5586
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Vol. 12 No. 5 (2024): GIIRJ
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Articles
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